Marvel Knights: Spider-Man #11 is the penultimate comic in the final Sub-Arc (The Last Stand) in the Marvel Knights: Spider-Man Collected Story-Arc.
- Black Cat
- Doctor Octopus (government controlled)
- Captain America
- Iron Man
- The Fantastic Four:
- Green Goblin
- Scorpion (as Venom)
Scorpion explains to the Green Goblin that he is the new Venom. Venom sees this as a good thing, but the Green Goblin doesn't, as it wasn't according to plan and Scorpion defied him. The Goblin then rides off, leaving Spider-Man and Black Cat to fight the reamining eleven members of the Sinister Twelve: Hydro-Man, Sandman, Lizard, Boomerang, Tombstone, Vulture, Electro, Chameleon, Shocker, Hammerhead, and the new Venom.
Spider-Man and Black Cat take advantage of the distraction and manage to get Sandman, Hydro-Man and the Lizard down, but Venom jumps from the rooftop onto Spider-Man and Electro shocks Cat when she tries to help him. Vulture wanted the Black Cat to himself, but everyone turns their attention to Spider-Man. Venom, still kneeling on Spider-Man, taunts him, saying that the Goblin has went to finish of Mary Jane.
This enrages Spider-Man and he tosses Venom far. All the members of the Sinister Twelve begin to overwelm him, but he still tries to fight. When things look hopeless, Captain America comes, leading behind him Daredevil, The Fantastic Four and Iron Man. They begin taking the villains and Spider-Man is confused on how they even found him.
Back at the Sinister Twelve battle ground, Spider-Man thanks Captain Americ, but leaves because he knows Mary Jane is in danger. Venom then attacks him and begins beating him. He then connects the symbiote to all surrounding buildings. He says he's not going to kill Spider-Man yet, he wants to watch Spider-Man's life crumble. He then pulls all the buildings down, endangering the pedestrians below. Spider-Man manages to create a web net to catch all the debris. He then beats Venom into submission and pulls a building on top of him.
Spider-Man passes a bridge and sees Green Goblin standing on his glider, holding Mary Jane over the water. "Look Familiar, Mister Parker?"